Proton pump inhibitors (ppi): towards rational prescription

Proton Pump Inhibitors: Omeprazole

Oral Proton Pump Inhibitors

There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability an...

Intravenous proton pump inhibitors.

Intravenous (IV) administration of a proton pump inhibitor (PPI) is a faster way to achieve gastric acid suppression than oral administration of the same agent. Peak suppression after IV administration occurs within hours, compared with several days later after oral administration. Thus the IV route of administration offers a faster onset of gastric suppression, achievement of intragastric pH c...

The interaction between clopidogrel and proton pump inhibitors (PPI): is there any clinical relevance?

The potential interaction between clopidogrel and proton pump inhibitors (PPI) in patients with acute coronary syndrome (ACS) raises serious concerns for cardiologists. However, in patients on this combination of drugs, there is no conclusive evidence of an increase in adverse cardiovascular events. From pharmacologic and pharmacodynamic perspectives, there is a real interaction between clopido...

PS212. Effects of Proton Pump Inhibitors (PPI) on the Serum Concentrations of Venlafaxine

s | 77 tasks was compared between before and after escitalopram administration. Methods: The subjects were 10 depressive outpatients (40.2 ± 7.6 years old) attending Kurume University Hospital. HAM-D was used to evaluate symptoms. Oxy-Hb value during the tasks were measured at bilateral recording points (22 on each side) using a multi-channel NIRS system. The subjects were instructed to phonat...